Department of Chemistry
Telephone: 787-832-4040 ext.2604
Research Areas: Pharmaceutical Materials, Near Infrared Chemical Imaging, Near Infrared, Spectroscopy, Raman Spectroscopy, Chemometrics
Research is focused on analyzing materials in their native structure without affecting their chemical or physical properties. Thus, near infrared and Raman spectroscopic methods of analysis are developed. Measurements are often made while pharmaceutical processes are occurring providing information on how these materials are transformed during processing. Three recent publications have described the effect of shear forces on pharmaceutical processes. The group’s research is performed in collaboration with scientists from the Engineering Research Center on Structured Organic Particulate Systems (http://ercforsops.org/)
The ultimate goal of the research is a new Quality Control where analytical labs are moved into the manufacturing area and are used to monitor, control and optimize processes.
- Ph.D. University of Georgia, 1986
- B.S. – University of New Orleans, 1982
1. A MPA™ (Multipurpose Analyzer) from Bruker Optics, which is capable of obtaining near infrared transmission spectra for tablets.
2. Two process NIR spectrometer from Control Development Incorporated (CDI) capable of performing real time measurements. Funding has been acquired for a third process NIR spectrometer, a Bruker Matrix system that should be installed before the end of 2014.
3. A Kaiser RXN-1 RA- 785 Raman spectrometer equipped with non-contact and immersion probes for reaction monitoring, and a wide area PhAT probe is also available.
4. A Spectral Dimensions SyNIRgi Chemical Imaging System with wavelength range extending from 1200 - 2450nm. This NIR-CI includes a Focal Plane Array detector where one pixel captures anentire spectrum, and makes it possible to capture 81,920 spectra within 3 minutes. A microscope with different objectives is used to vary spatial resolution and field of view from 3 x 2.5 mm to 40 x 32 mm, and is combined with tunable filters for wavelength selection The group also has several licenses of chemometrics software including Pirouette for Windows 4.02, SIMCA, the MATLAB® based PLS tool box, and the Modde software for design of experiments. These software packages have been an excellent resource in helping our students visualize and understand chemometrics.
The group has 4 modern personal computers, including two workstations.