Our research laboratory is committed to the development of novel antifungal formulations that are less cytotoxic to host cells, utilizing fundamental knowledge about biological interfaces and their interaction with soft biomaterials. We focus on the study of novel peptidomimetic materials with intrinsic antimicrobial properties based on β-amino acids as a platform for innovation in peptide science and their application to counteract microbial infections. Our research leads to the understanding of mechanisms of action of antimicrobial peptides; the study of multiple drug interaction (synergism) for the enhancement of existing antimicrobial therapies. The outcomes of our research may also be applied to the development of novel drug formulations and biomedical devices such as catheters, dressings, and implants.
- Postdoctoral Fellow. Biomolecular Chemistry, University of Wisconsin – Madison, 2007
- PhD. Microbiology, University of Wisconsin – Madison, 2005
- BS. Industrial Biotechnology, University of Puerto Rico – Mayagüez, 1999
Dr. Ortiz-Bermúdez leads the Microbial and Biochemical Engineering Laboratory (MBEL), a 450 square-feet space that has the essential equipment to carry out microbial cultivation and peptide synthesis. It is outfitted with 2 HPLC units (Waters Breeze and Shimadzu) with autoinjection, a CEM Mars 5 Microwave Oven, a Laminar Flow Hood, chemical hood, light microscope and miscellaneous equipment such as pH meters, ion selective electrodes, incubators (Precision, Eco and Sanyo), clinical centrifuges, several balances, glassware, etc. The laboratory of Dr. Ortiz-Bermúdez is also equipped with basic molecular biology equipments such as PCR machine (Eppendorf) and agarose gel electrophoresis chambers (Fisher/BioRad).