Oral immunization is a promising method to decrease access of allergens and pathogens to the body. Oral delivery of antigens is challenged by the anatomical conditions of the gastrointestinal tract, such as degradation by the acidic environment of the stomach and protein breakdown by proteases. The use of protein composite microcrystals to deliver antigens to the gastrointestinal tract is then an alternative to surpass these challenges. Composite microcrystals are engineered to contain hydrogel structures that promote crystallization, provide protection, and controlled release.
- Purdue University: Doctor of Philosophy in Chemical Engineering, August 2001
- Purdue University: Masters of Science in Chemical Engineering, May 1999
- University of Puerto Rico, Mayagüez Campus, Bachelor of Science in Chemical Engineering, May 1997
Biomaterials and Biomedical Engineering Laboratory, operated by Dr. Torres-Lugo:
Biomaterials and Biomedical Engineering Laboratory (667 ft2) is located in the Chemical Engineering Building at UPRM. This laboratory contains the infrastructure to perform general laboratory functions as well as cell culture work. It is outfitted with one laminar flow hood enclosed in a class 100 room, two chemical hoods, gas lines (air, vacuum), CO2 incubator with 48h battery backup, cryogenic tank, five digit balance, constant temperature water bath, deionized water system, microcentrifuge, vacuum drying oven, 96 well spectrofluromenter (Spectra Max Gemini EM), 96 well plate spectrophotometer, six Ussing chambers with heating block with CO2 perfusion, three side-by-side diffusion chambers (Permegear) fitted with Agilent and National Instrument data acquisition system, Olympus CKX41 inverted microscope, autoclave, glove box, EXFOS Acticure UV light source, Nitrogen generator, two constant temperature water baths. It also contains sit-down bench space, sinks, chemical hoods, refrigerator-freezers, and storage cabinets for hazardous chemicals.